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KISS1R Agonist · Hypothalamic Neuropeptide

KissPeptin-10
Research Compound

C-terminal decapeptide of kisspeptin (metastin). Binds KISS1R (GPR54) receptor. Available as lyophilized research sample in 5mg and 10mg vials — HPLC + MS verified, COA by Krause Analytical. For research use only.

5mg Vial 10mg Vial COA — Krause Analytical Reviewed: Sabrina Runbeck PA-C Finnrick Pulse Research Use Only
For Research Use Only. Not for Human Use. — All KissPeptin-10 research samples supplied by Sequence Labs are intended exclusively for laboratory and preclinical research purposes. Not for therapeutic, veterinary, or clinical application.

Compound Profile

What Is KissPeptin-10?

KissPeptin-10 (also designated kisspeptin-10 or Kp-10) is the biologically active C-terminal decapeptide fragment of kisspeptin, the full-length neuropeptide encoded by the KISS1 gene and historically referred to as metastin. The 10-residue sequence — Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂ — represents the minimal fragment that retains KISS1R receptor binding activity.

Published research has examined KissPeptin-10 as a selective agonist at the KISS1R receptor (also designated GPR54), a G-protein coupled receptor expressed in hypothalamic nuclei. The KISS1R receptor binding context of this peptide has positioned it as a tool compound in hypothalamic signaling research and neuroendocrine pathway studies conducted in preclinical animal models.

Research applications have included KISS1R receptor mechanism studies, HPG axis neuroendocrine research, and kisspeptin neuron mapping investigations in animal models. The compound is classified within the reproductive neuroendocrinology research domain, reflecting its role as a research tool in hypothalamic GnRH pulse studies in preclinical settings.

Sequence Labs supplies KissPeptin-10 as a lyophilized research sample at ≥98% purity, independently verified by HPLC and mass spectrometry via Krause Analytical, with a published COA available for each batch.

Technical Specifications

Common Name KissPeptin-10 / Kp-10
Also Known As Kisspeptin-10, Metastin C-terminal
Peptide Sequence Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂
Residues 10 amino acids (C-terminal decapeptide)
Molecular Formula C₆₃H₈₃N₁₇O₁₄
Molecular Weight ~1302 Da
CAS Number 374683-26-8
Target Receptor KISS1R (GPR54)
Purity (SL) ≥98% — HPLC + MS verified
Analytical Lab Krause Analytical
Form Lyophilized research sample
Available Sizes 5mg · 10mg

Research Classification

Research Background

Published research has examined KissPeptin-10 across several hypothalamic neuroendocrine research domains in preclinical and animal model settings. The following classifications reflect active areas in the peer-reviewed literature.

01

KISS1R (GPR54) Receptor Mechanism Research

Published research has examined KissPeptin-10's interaction with the KISS1R (GPR54) G-protein coupled receptor, including receptor binding kinetics, second messenger cascade studies, and structure-activity relationship investigations in preclinical models.

02

GnRH Pulse Regulation Research in Preclinical Models

Published research has examined the relationship between KISS1R activation by kisspeptin-10 and pulsatile GnRH secretion patterns in hypothalamic research conducted in preclinical animal models. This represents a well-characterized area of neuroendocrine systems research.

03

HPG Axis Neuroendocrine Research

Published research has examined KissPeptin-10's role in hypothalamic-pituitary-gonadal (HPG) axis signaling pathway research in animal models. This research classification covers upstream neuroendocrine regulatory pathway investigation.

04

Kisspeptin Neuron Mapping Research in Animal Models

Published research has examined the distribution and function of kisspeptin-expressing neurons in hypothalamic regions including the arcuate nucleus and anteroventral periventricular nucleus (AVPV) in animal model studies using kisspeptin-10 as a research tool.

05

Hypothalamic Signaling Pathway Research

Published research has examined downstream intracellular signaling cascades engaged by KISS1R activation — including phospholipase C, IP₃, and calcium mobilization — using KissPeptin-10 as a tool compound in preclinical hypothalamic signaling research.

PubMed Research Index View the indexed literature on kisspeptin, KISS1R, and GPR54 in the National Library of Medicine database.
Search PubMed →

Sequence Labs Supply

KissPeptin-10 Research Samples

KissPeptin-10 is available from Sequence Labs in two research vial sizes. Each batch is independently tested and supplied with a full certificate of analysis.

Research Sample
5mg
KissPeptin-10 · Lyophilized
~$55
  • Lyophilized research sample, single vial
  • ≥98% purity — HPLC verified
  • Mass spectrometry identity confirmation
  • COA by Krause Analytical — batch-level
  • Reviewed by Sabrina Runbeck PA-C
  • Finnrick Pulse quality notation
View Product
Best Value
10mg
KissPeptin-10 · Lyophilized
~$90
  • Lyophilized research sample, single vial
  • ≥98% purity — HPLC verified
  • Mass spectrometry identity confirmation
  • COA by Krause Analytical — batch-level
  • Reviewed by Sabrina Runbeck PA-C
  • Finnrick Pulse quality notation
View Product
HPLC + MS
Dual analytical verification
≥98%
Verified purity
Krause
Independent analytical lab
PA-C
Sabrina Runbeck — catalog review
COA
Published per batch

Reconstitution Reference

Preparing a KissPeptin-10 Research Sample

The following is a general reference for laboratory preparation of a lyophilized KissPeptin-10 research sample. For research use only. Not for human use.

  1. Allow the vial to reach ambient temperature. Remove the lyophilized KissPeptin-10 research sample vial from cold storage and allow it to equilibrate to room temperature before proceeding. This minimizes condensation and potential moisture uptake.
  2. Select an appropriate solvent. Bacteriostatic water (0.9% benzyl alcohol in sterile water for injection) is the most commonly used solvent for reconstituting lyophilized research peptides in laboratory settings. Sterile water may also be used where indicated in the research protocol.
  3. Introduce solvent slowly. Using a sterile syringe and needle, introduce the solvent into the lyophilized vial by directing the stream along the vial wall rather than directly onto the lyophilized cake. Introducing solvent in this way supports complete dissolution without mechanical disruption of the peptide matrix.
  4. Gently swirl — do not vortex. Gently rotate the vial between your fingers until the lyophilized material is fully dissolved. Do not vortex or shake vigorously, as this may cause aggregation of the peptide research sample.
  5. Inspect for complete dissolution. The reconstituted research sample solution should appear clear. If undissolved particulate remains, continue swirling gently. Discard if the solution remains cloudy or if visible contamination is present.
  6. Store per laboratory protocol. Reconstituted peptide research samples are generally stored at 2–8°C (refrigerator) and used within the timeframe specified by your laboratory's standard operating procedures. Long-term storage of the unreconstituted lyophilized vial is typically at −20°C.
Research Use Only. Not for Human Use. — This reconstitution reference is provided strictly for qualified researchers using KissPeptin-10 in approved laboratory settings. This information does not constitute medical guidance, clinical instruction, or endorsement of human use. All KissPeptin-10 research samples supplied by Sequence Labs are labeled for research use only. These statements have not been evaluated by the Food and Drug Administration.

Common Questions

KissPeptin-10 FAQ

Frequently asked questions about KissPeptin-10 research compound from Sequence Labs.

KissPeptin-10 (Kp-10) is the biologically active C-terminal decapeptide fragment of kisspeptin, the neuropeptide encoded by the KISS1 gene and also known historically as metastin. Its 10-amino acid sequence — Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂ — is the minimal fragment that retains KISS1R receptor binding activity. Molecular formula: C₆₃H₈₃N₁₇O₁₄, MW ~1302 Da, CAS 374683-26-8. Available from Sequence Labs as a lyophilized research sample for research use only. Not for human use.
KissPeptin-10 is studied as a selective agonist at the KISS1R receptor, also designated GPR54 — a G-protein coupled receptor expressed in hypothalamic nuclei. Published research has examined KISS1R receptor binding kinetics, downstream signaling cascades, and structure-activity relationships using KissPeptin-10 as a tool compound in preclinical models. For research use only. Not for human use.
Published research has examined KissPeptin-10 in the context of HPG axis neuroendocrine pathway studies, hypothalamic GnRH pulse regulation research in preclinical models, kisspeptin neuron mapping in animal models, and hypothalamic signaling pathway mechanism research. These represent research classification areas from peer-reviewed preclinical literature. For research use only. Not for human use.
Sequence Labs supplies KissPeptin-10 as a lyophilized research sample in 5mg (~$55) and 10mg (~$90) vials. Each batch is independently tested by Krause Analytical using HPLC and mass spectrometry, with a published certificate of analysis. Catalog is reviewed by Sabrina Runbeck PA-C. For research use only.
To prepare a KissPeptin-10 research sample, introduce bacteriostatic water or sterile water as solvent into the lyophilized vial by directing the stream along the vial wall. Swirl gently until fully dissolved — do not vortex. Store the reconstituted research sample at 2–8°C and use within your laboratory's protocol timeframe. Unreconstituted lyophilized samples are stored at −20°C. For research use only. Not for human use.
No. KissPeptin-10 supplied by Sequence Labs is strictly for research use only. It is not intended, labeled, or supplied for human use, veterinary use, or clinical application of any kind. All products are labeled "For Research Use Only. Not for Human Use." These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

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