Compound Identity
What Is Semaglutide?
Semaglutide is a synthetic glucagon-like peptide-1 (GLP-1) receptor agonist analog composed of 34 amino acids. It was developed as a long-acting GLP-1 analog and has been widely studied in the peer-reviewed literature. Sequence Labs supplies a research-grade analog for laboratory use only — not a finished drug product and not for human use.
The compound's molecular architecture is derived from native GLP-1(7–37), a naturally occurring incretin hormone. Semaglutide differs from native GLP-1 through two key structural modifications: a substitution at position 8 (replacing alanine with Aib, α-aminoisobutyric acid) to resist DPP-4 enzymatic cleavage, and the attachment of a C18 fatty diacid chain via a linker at lysine-26. This acylation enables albumin binding in plasma, dramatically extending the compound's half-life from the minutes seen with native GLP-1 to approximately one week.
Molecular specifications: Semaglutide is a 34-amino-acid synthetic peptide (C₁₈₇H₂₉₁N₄₅O₅₉, MW ≈ 4,113.58 Da) featuring a C18 fatty diacid moiety attached via an OEG-OEG-gamma-Glu-mini-PEG linker at Lys²⁶. CAS: 910463-68-2.
- Class: GLP-1 receptor agonist (GLP-1RA) — long-acting synthetic incretin analog
- Origin: Developed by Novo Nordisk; structurally derived from human GLP-1(7–37)
- Structural modification: Position-8 Aib substitution plus C18 fatty diacid chain for albumin binding
- Sequence origin: 94% sequence homology to human GLP-1; altered at 2 positions relative to natural sequence
- Research form: Supplied lyophilized (white to off-white powder) for research sample preparation
Published Research
Research Background
Semaglutide is among the most extensively studied GLP-1 receptor agonists in published scientific literature, with hundreds of peer-reviewed studies examining its receptor binding properties, incretin signaling mechanisms, and effects in various preclinical and in vitro models. The research interest spans multiple biological systems where GLP-1 receptors are expressed.
Sequence Labs Supply
Available Sizes, Testing & COA
Sequence Labs offers research-grade semaglutide in five lyophilized vial sizes. Every batch undergoes independent third-party testing through Krause Analytical in Austin, TX, with batch-specific COAs publicly accessible and verifiable via Finnrick Pulse.
| Size | Price | Form | COA | Stock |
|---|---|---|---|---|
| 5 mg | $43.99 | Lyophilized vial | ✓ Batch COA | In Stock |
| 10 mg | $70.99 | Lyophilized vial | ✓ Batch COA | In Stock |
| 15 mg | $97.99 | Lyophilized vial | ✓ Batch COA | In Stock |
| 20 mg | $128.99 | Lyophilized vial | ✓ Batch COA | In Stock |
| 30 mg | $148.99 | Lyophilized vial | ✓ Batch COA | In Stock |
Wholesale available. Research institutions, laboratories, and qualified researchers can apply for tiered pricing — typically 18–32% below retail with no monthly commitment. View wholesale terms →
Laboratory Handling
Receiving, Storage & COA
Semaglutide ships as a sealed lyophilized research vial. Receiving, inventory, and any subsequent laboratory preparation follow your institution’s protocols and the batch Certificate of Analysis. Sequence Labs does not publish reconstitution recipes, solvent volumes, or administration how-to.
- Inspect the sealed vial. Confirm the crimp is intact and the lyophilized material appears as a white to off-white powder or cake consistent with a sealed research vial.
- Match the batch COA. Verify the lot number against the Krause Analytical Certificate of Analysis before releasing the vial into laboratory inventory.
- Store sealed. Keep lyophilized vials protected from light and moisture. Refrigerated storage is the usual default unless the COA or your SOP specifies otherwise.
- Follow institutional SOP. Solvent choice, volumes, and in-use handling are determined by the qualified investigator — not by Sequence Labs.
For research use only. All handling must comply with applicable institutional, state, and federal regulations governing research materials. Sequence Labs semaglutide is not a medicine and is not for human use.
Frequently Asked Questions
Semaglutide Research FAQ
Ready to Order?
Research-grade semaglutide, verified and in stock
Five sizes, batch COA from Krause Analytical, reviewed by reviewed by Sabrina Runbeck, PA-C. Order direct or apply for wholesale pricing.