Semax is a synthetic heptapeptide analog of ACTH(4-7) developed by the Institute of Molecular Genetics of the Russian Academy of Sciences. Its amino acid sequence is Met-Glu-His-Phe-Pro-Gly-Pro, where Met-Glu-His-Phe is the ACTH(4-7) core and Pro-Gly-Pro is a C-terminal extension added for enhanced stability. CAS: 80714-61-0. Molecular formula: C37H51N9O10S. MW: ~838 Da. For research use only.

What sizes does Sequence Labs offer for Semax?

Sequence Labs offers Semax in two research vial sizes: 5mg (~$40) and 10mg (~$65). Each vial is lyophilized, HPLC and mass spectrometry tested by Krause Analytical, and accompanied by a Certificate of Analysis. For research use only.

How is Semax reconstituted for research use?

For research sample preparation, bacteriostatic water (BW) is the recommended solvent. Introduce solvent slowly along the vial wall using a sterile syringe — do not agitate. The reconstituted research sample should be stored at 2–8°C and used within 30 days. Standard research practice: introduce 1–2 mL of BW per 5mg research vial. For research use only. Not for human use.

Semax Research Compound | ACTH Analog

Q: What is the ACTH(4-7) connection?

Semax is structurally derived from the 4–7 fragment of adrenocorticotropic hormone (ACTH). The Met-Glu-His-Phe core sequence corresponds to ACTH residues 4 through 7. Published research has examined how this ACTH-derived core interacts with melanocortin receptor subtypes in preclinical models. The Pro-Gly-Pro extension differentiates Semax from a direct ACTH(4-7) fragment and is the subject of separate peptide stability research.

Q: What BDNF research involves Semax?

Published preclinical research has examined Semax's relationship to the BDNF (brain-derived neurotrophic factor) and NGF (nerve growth factor) signaling pathways in animal models. This research is conducted under controlled laboratory conditions. Sequence Labs supplies Semax exclusively as a research sample for qualified researchers. For research use only — not for human use.

Q: Is Semax for human use?

No. Semax from Sequence Labs is supplied exclusively as a research compound for qualified laboratory researchers and licensed professionals conducting preclinical or in-vitro research. It is not approved by the FDA for human use, and is not intended to diagnose, treat, cure, or prevent any disease or condition. For research use only. Not for human use.

Compound Profile

What Is Semax?

Semax is a synthetic heptapeptide classified as an ACTH analog neuropeptide. Its structure is based on the 4–7 fragment of adrenocorticotropic hormone (ACTH), extended with a Pro-Gly-Pro tripeptide tail. The full amino acid sequence — Met-Glu-His-Phe-Pro-Gly-Pro — was developed at the Institute of Molecular Genetics of the Russian Academy of Sciences.

The ACTH(4-7) core (Met-Glu-His-Phe) represents the biologically relevant fragment of ACTH studied for receptor binding characteristics in preclinical models. The Pro-Gly-Pro C-terminal extension was incorporated to enhance metabolic stability relative to the native ACTH(4-7) fragment, and is itself the subject of separate neuropeptide signaling research.

Semax is classified as a research compound and is supplied by Sequence Labs as a lyophilized research sample for in-vitro and preclinical research applications. For research use only. Not for human use.

Amino Acid Sequence

Met · Glu · His · Phe · Pro · Gly · Pro

[ ACTH(4-7) core: Met-Glu-His-Phe ] + [ Pro-Gly-Pro stability extension ]

Specifications

Common Name	Semax
Classification	ACTH Analog Neuropeptide
Peptide Type	Heptapeptide (7 AA)
Sequence	Met-Glu-His-Phe-Pro-Gly-Pro
Origin	ACTH(4-7) + Pro-Gly-Pro
Molecular Formula	C₃₇H₅₁N₉O₁₀S
Molecular Weight	~838 Da
CAS Number	80714-61-0
Developer	Inst. of Molecular Genetics, RAS
Research Classification	ACTH Analog / Neuropeptide
Available Sizes	5mg · 10mg
Storage	Lyophilized, −20°C long-term
Purity	≥99% (HPLC + MS verified)
Testing Lab	Krause Analytical
Use Classification	Research use only

Preclinical Research Areas

Research Background

Published research has examined Semax across several neuropeptide signaling domains using preclinical animal models. The following areas represent documented research classifications.

BDNF / NGF Pathway Research in Preclinical Models

Published research has examined Semax in the context of BDNF (brain-derived neurotrophic factor) and NGF (nerve growth factor) signaling in animal models. This BDNF pathway research is conducted under controlled preclinical laboratory conditions and characterizes Semax as a tool compound for studying neurotrophic factor interactions.

ACTH Receptor Mechanism Research

Published research has examined how the ACTH(4-7) core sequence of Semax interacts with melanocortin receptor subtypes. This ACTH receptor mechanism research uses Semax as a structural probe to investigate binding selectivity and downstream signaling in preclinical model systems.

Neuropeptide Signaling Pathway Research

As an ACTH analog neuropeptide, Semax has been used in published research to characterize neuropeptide signaling cascades. Research publications have examined how the heptapeptide structure — particularly the Pro-Gly-Pro extension — modulates signaling duration and pathway selectivity relative to the native ACTH(4-7) fragment.

Monoamine System Research in Animal Models

Published research has examined Semax in relation to dopamine and serotonin pathway dynamics in animal models. This monoamine system research uses Semax as a research tool to probe catecholamine and indoleamine neurotransmitter signaling under controlled laboratory conditions.

Neuroplasticity Pathway Research in Preclinical Models

Published preclinical research has examined Semax in neuroplasticity pathway studies using animal models. This neuroplasticity research investigates synaptic remodeling-related signaling mechanisms in controlled research settings and is distinct from any clinical or human-use application.

Published research index: Peer-reviewed publications examining Semax in ACTH analog and BDNF pathway contexts are indexed in the National Library of Medicine's PubMed database.

PubMed Index

Russian Neuropeptide Research Compounds

Semax vs. Selank

Both Semax and Selank are synthetic neuropeptide research compounds developed by Russian Academy of Sciences institutes. Published research has examined each through distinct mechanistic pathways in preclinical models.

This Compound

Semax

Origin: Institute of Molecular Genetics, RAS
Structure: ACTH(4-7) analog heptapeptide — Met-Glu-His-Phe-Pro-Gly-Pro
Pathway research: ACTH receptor mechanism, BDNF/NGF pathway, monoamine system
Core fragment: ACTH(4-7) with Pro-Gly-Pro stability extension
MW: ~838 Da · CAS: 80714-61-0
SL sizes: 5mg · 10mg

Related Compound

Selank

Origin: Institute of Molecular Genetics, RAS
Structure: Tuftsin (Thr-Lys-Pro-Arg) + Gly-Glu-Pro extension
Pathway research: Tuftsin receptor research, GABA_A modulatory pathway, anxiolytic signaling research
Core fragment: Immunomodulatory tuftsin-derived tetrapeptide
Research page: selank-research.html
Combined page: semax-selank-research.html

Sequence Labs Supply

Semax Research Vials

HPLC and mass spectrometry tested by Krause Analytical. Certificate of Analysis on every batch. Reviewed by Sabrina Runbeck, PA-C. For research use only.

5mg Vial

~$40 / research vial

5mg lyophilized Semax research sample
HPLC + MS tested — Krause Analytical
Certificate of Analysis included
≥99% purity verified
Reviewed: Sabrina Runbeck, PA-C
Reviewed: Finnrick Pulse
For research use only

10mg Vial

~$65 / research vial

10mg lyophilized Semax research sample
HPLC + MS tested — Krause Analytical
Certificate of Analysis included
≥99% purity verified
Reviewed: Sabrina Runbeck, PA-C
Reviewed: Finnrick Pulse
Best value per mg research sample
For research use only

Testing Lab

Krause Analytical

Test Methods

HPLC + Mass Spectrometry

Purity Standard

≥99% Verified

Catalog Review

Sabrina Runbeck, PA-C

Additional Review

Finnrick Pulse

Use Classification

Research Use Only

Research Sample Preparation

Reconstitution Reference

Standard research laboratory protocol for preparing lyophilized Semax research samples. For research use only. Not for human use.

Prepare Solvent

Bacteriostatic water (BW) is the standard solvent for Semax research sample preparation. Confirm sterility of all materials before beginning.

Introduce Solvent

Introduce the solvent slowly along the inner wall of the vial using a sterile syringe. Standard research reference: 1–2 mL bacteriostatic water per 5mg research vial.

Dissolve Without Agitation

Allow the lyophilized research sample to dissolve by gentle rotation. Do not shake or vortex. Semax is water-soluble and should dissolve completely without agitation.

Store Reconstituted Sample

Store reconstituted research sample at 2–8°C. Use within 30 days. Lyophilized vials may be stored at −20°C long-term prior to reconstitution.

Research use only. This reconstitution reference is provided for qualified laboratory researchers preparing Semax research samples for in-vitro or preclinical preclinical studies. This information is not instruction for human use. Sequence Labs supplies Semax exclusively as a research compound. Not for human use.

Common Questions

Semax Research FAQ

What is Semax?

Semax is a synthetic heptapeptide analog of ACTH(4-7) developed by the Institute of Molecular Genetics of the Russian Academy of Sciences. Its full amino acid sequence is Met-Glu-His-Phe-Pro-Gly-Pro — a seven-residue peptide where the first four residues (Met-Glu-His-Phe) constitute the ACTH(4-7) core, and the final three (Pro-Gly-Pro) form a stability-enhancing C-terminal extension. CAS number: 80714-61-0. Molecular formula: C₃₇H₅₁N₉O₁₀S. MW: ~838 Da. Sequence Labs supplies Semax as a research compound for research use only.

What is the ACTH(4-7) connection?

Semax is structurally derived from residues 4 through 7 of adrenocorticotropic hormone (ACTH). The Met-Glu-His-Phe core sequence represents this ACTH(4-7) fragment. Published research has examined how this ACTH-derived core interacts with melanocortin receptor subtypes in preclinical models. The addition of the Pro-Gly-Pro extension distinguishes Semax from a simple ACTH(4-7) fragment and is itself the subject of separate neuropeptide stability research.

What BDNF pathway research involves Semax?

Published preclinical research has examined Semax in the context of BDNF (brain-derived neurotrophic factor) and NGF (nerve growth factor) signaling pathways using animal models. This research is conducted under controlled laboratory conditions and uses Semax as a research tool compound for studying neurotrophic signaling. Published research examining Semax in relation to BDNF pathway activity is indexed on PubMed at pubmed.ncbi.nlm.nih.gov/?term=semax+ACTH+BDNF. Sequence Labs supplies Semax for research use only — not for human use.

What sizes does Sequence Labs offer?

Sequence Labs offers Semax in two research vial sizes: 5mg (approximately $40) and 10mg (approximately $65). Each vial contains lyophilized Semax research sample, tested by Krause Analytical using HPLC and mass spectrometry, with purity ≥99% verified. A Certificate of Analysis is available for every batch. Catalog has been reviewed by Sabrina Runbeck, PA-C and Finnrick Pulse. For research use only.

How is the research sample reconstituted?

For research sample preparation, bacteriostatic water is the standard solvent. Introduce the solvent slowly along the inner vial wall using a sterile syringe — do not agitate. A standard research reference point is 1–2 mL of bacteriostatic water per 5mg research vial. Store the reconstituted research sample at 2–8°C and use within 30 days. This reconstitution reference is for qualified laboratory researchers only. For research use only. Not for human use.

Is Semax for human use?

No. Semax from Sequence Labs is classified as a research compound and is supplied exclusively for in-vitro and preclinical research purposes by qualified laboratory researchers and licensed professionals. It is not approved by the U.S. Food and Drug Administration for human use, and is not intended to diagnose, treat, cure, or prevent any disease or condition in humans or animals. All products carry the classification: For research use only. Not for human use.

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Related Resources

Full Catalog

Products & Pricing

Browse Semax, Selank, and the complete Sequence Labs research compound catalog with current pricing and availability.

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Related Compound

Selank Research Compound

Tuftsin-derived heptapeptide from the Russian Academy of Sciences. GABA modulatory pathway and anxiolytic signaling research. 5mg and 10mg vials.

View Selank Page →

Compound Comparison

Semax & Selank Research

Side-by-side comparison of both Russian neuropeptide research compounds — ACTH/BDNF pathway versus tuftsin/GABA pathway research classifications.

View Comparison →

Inquiries

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Semax ResearchCompound