Compound Identity
HGH (Somatropin) at a Glance
Recombinant human growth hormone — a 191-amino-acid single-chain polypeptide produced in E. coli via rDNA technology. Sequence-identical to endogenous pituitary GH. Extensive peer-reviewed research characterizes its effects on the GH/IGF-1 axis, body composition, and lipid metabolism.
Compound Class
Recombinant human growth hormone (somatropin)
CAS Number
12629-01-5
Molecular Formula
C⌡₀₁H₁₁₆₂N₁₈₆O₃₀₂S₄
Molecular Weight
~22,124 Da (22.1 kDa)
Amino Acid Length
191 residues, single chain, two disulfide bridges
Receptor Target
Growth hormone receptor (GHR); indirect via IGF-1
Sequence Identity
100% homologous to endogenous 22 kDa human pituitary growth hormone
Research Background
Published Literature
Peer-reviewed research characterizes HGH (Somatropin)'s receptor pharmacology, biochemistry, and biological activity across multiple domains. Sequence Labs supplies research-grade material; all product use is subject to laboratory research protocols and applicable regulations.
GH / IGF-1 Axis
Recombinant human growth hormone binds the GH receptor dimer, activating JAK2/STAT5 signaling. Hepatic response includes IGF-1 synthesis. Serum IGF-1 is the standard biomarker of systemic GH exposure in research.
Body Composition
Multiple randomized studies in GH-deficient adults document reductions in visceral adipose tissue and increases in lean body mass with recombinant somatropin over 6-12 month intervals.
Lipid Metabolism
Growth hormone activates hormone-sensitive lipase, promoting lipolysis. Research reports elevations in free fatty acids and reductions in LDL-C with sustained GH exposure.
Insulin Sensitivity
GH is diabetogenic at supraphysiologic levels. Research characterizes counter-regulatory effects on insulin action — a monitored parameter in all clinical GH studies.
Independent research publications on HGH (Somatropin) are indexed in the NIH PubMed database. Consult primary literature for detailed methodology, dosing, and outcomes across research contexts.
Search PubMedSequence Labs Supply
Available Vial Sizes
All vials lyophilized under nitrogen with silver aluminum crimp cap and ivory-label spec. Manufacture and expiration dates printed. Batch-specific COA published in the COA library.
Somatropin (HGH)
10 IU Kit
$85 / kit
10 IU lyophilized vial + 3ml bacteriostatic water. Silver crimp cap.
Somatropin (HGH)
100 IU Kit
$725 / kit
10 vials of 10 IU each. Kit configuration. Bulk pricing per IU.
Somatropin (HGH)
300 IU Kit
$1,995 / kit
30 vials of 10 IU. Research-institution volume.
Quality Standards
HPLC + Mass Spec
Every batch, reverse-phase HPLC purity confirmation plus MS molecular weight identity. Chromatograms published.
ISO 17025 Lab
Analytical testing performed by ISO 17025 accredited independent laboratory. Full documentation.
Cold-Chain Shipped
Insulated packaging with -20°C gel packs. 3-day standard, overnight available.
Silver Crimp Caps
Tamper-evident silver aluminum crimp caps. Lyophilized under nitrogen. Ivory-label spec.
Reconstitution Reference
Standard Procedure
Reconstitution protocol for research-grade lyophilized HGH (Somatropin). Adjust diluent volume to reach the working concentration required by the research protocol.
Prepare Materials
Remove vial and bacteriostatic water from cold storage. Allow to reach room temperature (~15-20 minutes). Have a sterile insulin syringe (U-100) ready.
Sterilize Vial Tops
Wipe both the HGH vial rubber stopper and the bacteriostatic water vial rubber stopper with 70% isopropyl alcohol. Allow to air-dry for 15-30 seconds.
Draw Diluent
Draw 1 mL of bacteriostatic water into the syringe. This produces a working concentration of 10 IU / mL for a 10 IU vial.
Add Diluent to Peptide
Insert needle into the HGH vial at an angle so the diluent runs down the inside glass wall. Do NOT inject directly onto the powder pellet. Never shake.
Swirl to Dissolve
Gently swirl or roll the vial between palms until fully dissolved (~30 seconds). The solution should be clear and colorless. Cloudy solutions indicate improper reconstitution.
Label + Store
Label the vial with reconstitution date. Refrigerate at 2-8°C. Reconstituted somatropin is stable for approximately 14-21 days when properly refrigerated.
Frequently Asked Questions
HGH (Somatropin) FAQ
What makes HGH somatropin different from other growth hormone products?
Somatropin is the recombinant 191-amino-acid form — sequence-identical to endogenous human pituitary GH. Somatrem (Protropin) had an extra methionine and is no longer used. Modern research grade HGH is somatropin produced via E. coli or mammalian expression systems.
Why is HGH sold as a kit?
The kit format includes the lyophilized peptide plus bacteriostatic water diluent required for reconstitution. Because HGH must be reconstituted with the correct diluent volume to achieve documented concentration, shipping both together ensures researchers have exactly what the protocol calls for.
What is IU vs mg for HGH?
One IU (International Unit) of somatropin corresponds to approximately 0.333 mg. A 10 IU vial contains ~3.33 mg of somatropin. IU is the historical unit standardized against a WHO reference preparation and remains standard in HGH literature.
How long is reconstituted HGH stable?
Approximately 14-21 days when reconstituted with bacteriostatic water and refrigerated at 2-8°C, per manufacturer stability data for research-grade somatropin. Sterile water reconstitution is stable for a shorter window (~24 hours refrigerated).
What testing is performed on each batch?
Reverse-phase HPLC purity, mass spectrometry identity confirmation (~22,124 Da target), endotoxin (LAL), residual host cell protein, bioburden, and appearance. Full COA published per batch.
Order HGH (Somatropin) Research Material
Batch-tested lyophilized vials with published COA. Standard 3-day cold-chain shipping $15. Overnight $30. Same-day dispatch on orders before 2pm ET.