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Recombinant Somatropin · GH Receptor Research

HGH Research Compound

191-amino acid recombinant polypeptide. GH receptor mechanism research compound, independently verified by Krause Analytical. Available in 10 IU and 15 IU research vials.

10 IU Vial 15 IU Vial COA: Krause Analytical Reviewed: Sabrina Runbeck PA-C Finnrick Pulse Verified HPLC + MS Tested
⚑  For Research Use Only — Not for Human Use

Compound Profile

What Is HGH (Recombinant Somatropin)?

Human Growth Hormone (HGH), designated somatropin in its recombinant form, is a 191-amino acid single-chain polypeptide produced naturally by somatotroph cells located in the anterior pituitary gland. Its molecular weight is approximately 22,124 daltons with a molecular formula of C990H1529N263O299S7.

For research applications, recombinant human growth hormone (r-hGH) is synthesized using recombinant DNA technology — typically expressed in E. coli or mammalian cell systems — to produce a sequence-identical polypeptide to the endogenous molecule. This recombinant production context is the basis for its research compound classification.

Published research has examined how r-hGH interacts with the GH receptor (GHR) at the molecular level. GHR belongs to the cytokine receptor superfamily. Upon GH binding, the receptor undergoes conformational dimerization, recruiting and activating JAK2 (Janus kinase 2). JAK2 subsequently phosphorylates STAT5 (Signal Transducer and Activator of Transcription 5), which translocates to the nucleus — making the GHR/JAK2/STAT5 axis a central subject of somatotropin receptor research in preclinical models.

As a research compound, HGH is classified within the GH receptor agonist category and carries dual-use pharmaceutical context. Researchers handling this compound must comply with all applicable federal, state, and institutional regulatory frameworks.

GHR Binding JAK2 Activation STAT5 Phosphorylation IGF-1 Axis Research Somatotroph Biology

Compound Specifications

Compound HGH / Somatropin
CAS Number 12629-01-5
Mol. Formula C990H1529N263O299S7
Mol. Weight ~22,124 Da
Chain Length 191 amino acids
Type Recombinant polypeptide
Origin Anterior pituitary (endogenous)
Target Receptor GHR (GH Receptor)
Signaling JAK2 / STAT5
Form Lyophilized powder
Purity (SL) ≥99% (HPLC + MS)
Research Use In vitro / preclinical only

Research Classification Notice: Recombinant HGH carries dual-use pharmaceutical context. Researchers must be aware of applicable federal regulations and institutional protocols governing GH-axis compounds in their jurisdiction. For research use only. Not for human use.

Published Research Areas

Research Background

Published research has examined recombinant somatropin across several molecular and cellular biology domains in preclinical and in vitro models. The following areas represent principal research contexts in the scientific literature.

⚙

GH Receptor Mechanism & JAK2/STAT5 Signaling Research

Published research has examined the structural basis of GH–GHR interaction, including the sequential receptor dimerization event that initiates JAK2 kinase activation and subsequent STAT5 phosphorylation. Preclinical model research in this area has clarified ligand–receptor binding kinetics and downstream transcriptional regulation.

🔬

IGF-1 Axis Production Research in Preclinical Models

Published research has examined how GHR signaling in hepatic preclinical models relates to IGF-1 (Insulin-like Growth Factor 1) gene expression. The somatotropic axis — hypothalamic GHRH → pituitary GH → hepatic IGF-1 — has been a subject of endocrinology research in rodent and cell culture models.

🦴

Skeletal Growth Plate Research in Animal Models

Published research has examined the role of GH receptor signaling in chondrocyte proliferation and differentiation at the epiphyseal growth plate in animal models. These studies have informed the mechanistic understanding of long bone growth plate biology in research contexts.

⚡

Metabolic Pathway Research in Preclinical Models

Published research has examined GHR-mediated effects on substrate metabolism in preclinical models, including research into carbohydrate and lipid pathway modulation downstream of JAK2/STAT5 signaling. These represent areas of ongoing metabolic biology research.

🧫

Adipose Tissue Research in Preclinical Models

Published research has examined GH receptor expression and GHR-mediated signaling in adipocyte preclinical models. Research into lipolytic pathway regulation via JAK2/STAT5 in adipose cell lines represents an active area of receptor biology investigation.

Browse GHR Mechanism Research on PubMed →

External resource. Published research literature on PubMed. For informational reference only.

Research Context Comparison

Direct GH vs. Secretagogue Pathway Research

In research models, direct recombinant GH (somatropin) and GHRH-pathway secretagogues engage the GH signaling cascade through distinct upstream mechanisms. Researchers select compound class based on the specific node of the somatotropic axis under investigation.

Direct GH Agonist

Recombinant HGH
(Somatropin)

  • Binds GHR directly at cell surface in research models
  • Initiates GHR dimerization → JAK2 activation without upstream GHRH pathway involvement
  • Used in research examining GHR-distal signaling nodes and receptor saturation kinetics
  • 191-AA polypeptide; MW ~22,124 Da; CAS 12629-01-5
  • Research does not depend on somatotroph cell function in preclinical models

GHRH Analog (Secretagogue)

Sermorelin / CJC-1295
(GHRH-R Agonists)

  • Activates GHRH receptor on somatotroph cells in preclinical research models
  • Stimulates endogenous GH release from pituitary somatotrophs — upstream of GHR
  • Research examines GHRH-R–mediated signaling and pulsatile GH release dynamics
  • Sermorelin: 29-AA fragment; CJC-1295: DAC-modified GHRH analog
  • Preclinical model function depends on intact somatotroph cell capacity

GHS-R Agonist (Ghrelin Mimetic)

Ipamorelin
(GHS-R1a Agonist)

  • Activates GHS-R1a (ghrelin receptor) — distinct receptor from GHRH-R
  • Research examines GHS-R pathway–mediated GH release dynamics in preclinical models
  • 5-AA pentapeptide; selective GHS-R1a binding profile studied in preclinical research
  • Often combined with GHRH analogs in preclinical model research examining synergistic GH release
  • Upstream of GHR; does not directly bind GHR in receptor mechanism research

Sequence Labs Supply

HGH Research Compound — Available Vials

Lyophilized recombinant somatropin research compound. Each vial independently tested by Krause Analytical (HPLC + MS). Reviewed by Sabrina Runbeck, PA-C. Verified by Finnrick Pulse. For research use only.

10 IU

HGH Research Vial · Lyophilized

~$85

  • Recombinant somatropin research compound
  • Lyophilized powder — reconstitute with bacteriostatic water
  • HPLC + Mass Spectrometry verified — Krause Analytical
  • ≥99% purity verified
  • COA available — batch-level transparency
  • Reviewed by Sabrina Runbeck, PA-C
  • For research use only. Not for human use.
Inquire — 10 IU
Most Requested

15 IU

HGH Research Vial · Lyophilized

~$115

  • Recombinant somatropin research compound
  • Lyophilized powder — reconstitute with bacteriostatic water
  • HPLC + Mass Spectrometry verified — Krause Analytical
  • ≥99% purity verified
  • COA available — batch-level transparency
  • Reviewed by Sabrina Runbeck, PA-C
  • For research use only. Not for human use.
Inquire — 15 IU
HPLC + MS
Dual-method verification
≥99%
Verified purity
Krause
Analytical COA lab
PA-C
Sabrina Runbeck — catalog review
Finnrick
Pulse supply verification

Laboratory Reference

Reconstitution Reference for Research Use

Lyophilized HGH research compound requires solvent introduction prior to laboratory use. The following protocol describes standard laboratory reconstitution practice for research purposes only.

01

Prepare Solvent

Use bacteriostatic water (BAC water, 0.9% benzyl alcohol in sterile water, USP) as the reconstitution solvent. BAC water is the standard solvent for lyophilized polypeptide research samples due to its antimicrobial preservative properties.

02

Introduce Solvent

Introduce solvent slowly by directing it down the inside wall of the vial — not directly onto the lyophilized cake. This minimizes foam and mechanical disruption of the polypeptide chain. Do not agitate or vortex the research sample.

03

Gentle Rotation

After solvent introduction, gently rotate the vial between fingers to allow complete solubilization of the lyophilized powder. Avoid vigorous shaking. Allow the research sample to solubilize fully before proceeding with laboratory work.

04

Storage of Reconstituted Sample

Store reconstituted research sample refrigerated at 2–8°C (36–46°F). Protect from light. Lyophilized (unreconstituted) research compound may be stored at −20°C for extended research periods. Follow institutional storage protocols.

This reconstitution reference is provided for research laboratory informational purposes only. This product is not intended for human use, therapeutic use, or any use outside of a properly permitted research laboratory setting. Researchers must comply with all applicable institutional, state, and federal protocols for handling polypeptide research compounds with dual-use pharmaceutical classification. For research use only.

Frequently Asked Questions

HGH Research Compound FAQ

HGH (Human Growth Hormone), designated somatropin in its recombinant form, is a 191-amino acid single-chain polypeptide naturally produced by somatotroph cells in the anterior pituitary. As a research compound, recombinant HGH (r-hGH) is produced via recombinant DNA technology and used to investigate GH receptor (GHR) signaling, JAK2/STAT5 pathway mechanics, and related somatotropic axis biology in preclinical and in vitro models. CAS: 12629-01-5. MW: ~22,124 Da. Molecular formula: C990H1529N263O299S7. For research use only. Not for human use.
In preclinical research models, these compound classes operate at distinct nodes of the somatotropic axis. Recombinant HGH (somatropin) binds the GH receptor (GHR) directly, initiating receptor dimerization and JAK2/STAT5 activation without upstream pituitary involvement. GHRH analogs such as Sermorelin and CJC-1295 activate the GHRH receptor on somatotroph cells to stimulate endogenous GH release — they are upstream secretagogues. GHS-R1a agonists such as Ipamorelin operate via the ghrelin receptor, an additional distinct upstream pathway. Researchers select between these compound classes based on which node of the GH signaling cascade is the subject of investigation. All are for research use only. Not for human use.
Published research has examined the GHR/JAK2/STAT5 signaling cascade extensively in preclinical models. GHR is a member of the cytokine receptor superfamily. When recombinant GH binds GHR, the receptor undergoes dimerization, transactivating associated JAK2 (Janus kinase 2). JAK2 phosphorylates STAT5 (Signal Transducer and Activator of Transcription 5), which forms dimers and translocates to the nucleus to regulate transcription of downstream target genes — including those in the IGF-1 axis — in preclinical research models. This pathway is a central focus of GH receptor mechanism research.
Sequence Labs carries recombinant HGH (somatropin) research compound in two vial sizes: 10 IU (~$85) and 15 IU (~$115). Both are provided as lyophilized powder. All batches are independently tested by Krause Analytical using HPLC and mass spectrometry to ≥99% purity. A Certificate of Analysis (COA) is available for every batch. The catalog has been reviewed by Sabrina Runbeck, PA-C. For research use only. Not for human use.
For laboratory reconstitution: introduce bacteriostatic water (BAC water — 0.9% benzyl alcohol in sterile water) slowly down the inside wall of the vial. Do not agitate vigorously — gently rotate to allow the solvent to solubilize the lyophilized research sample. Store the reconstituted sample refrigerated at 2–8°C, protected from light. Unreconstituted lyophilized research compound may be stored at −20°C per institutional protocol. This reference is for research laboratory informational purposes only. For research use only. Not for human use.
No. Sequence Labs HGH (recombinant somatropin) is strictly for in vitro and preclinical research use only. It is not intended for human use, is not a drug product, and has not been evaluated by the Food and Drug Administration for any therapeutic, diagnostic, or preventive purpose. Recombinant HGH carries dual-use pharmaceutical classification context. All researchers and purchasers must comply with applicable federal, state, and institutional regulations governing this class of research compound in their jurisdiction. Not for human use.

Related Research Compounds

GH Axis Research Compounds

Other GH-pathway secretagogue research compounds available from Sequence Labs for comparative and multi-node research models.

GHRH Analog

Sermorelin

29-amino acid GHRH analog. Published research has examined GHRH-R–mediated somatotroph stimulation in preclinical models. HPLC + MS verified.

GHS-R1a Agonist

Ipamorelin

Selective GHS-R1a agonist (ghrelin mimetic). Published research has examined GHS-R1a–mediated GH release dynamics in preclinical models. HPLC + MS verified.

Full GH Stack

CJC-1295 & More

Full GH secretagogue research catalog including CJC-1295 (DAC and non-DAC), Tesamorelin, and AOD 9604. View all GH axis compounds.

Wholesale / Inquiry

Contact Sequence Labs

Questions about HGH research compound sourcing, COA documentation, or wholesale research supply? Contact us directly.

Inquire About HGH Research Compound

For research use only. HPLC + MS verified by Krause Analytical. Reviewed by Sabrina Runbeck, PA-C. 10 IU and 15 IU vials available.

Browse Full Catalog Inquire Now COA Library

For research use only. Not for human use. Not for veterinary use without appropriate licensing. These products have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Researchers must comply with all applicable federal, state, and institutional regulations.