These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease. For research use only.  Legal & Disclaimer

GHRH(1-29) · Endogenous GH Secretagogue Analog

Sermorelin Research Compound

29-amino acid N-terminal fragment of endogenous GHRH. Studied in preclinical models for GHRH receptor binding and somatotroph cell research. For research use only. Not for human use.

5mg Vial 10mg Vial COA · Krause Analytical Finnrick Pulse Reviewed · Sabrina Runbeck PA-C

Compound Overview

What Is Sermorelin?

Sermorelin — formally designated GHRH(1-29)NH2 — is a synthetic 29-amino acid peptide corresponding to the biologically active N-terminal fragment of endogenous growth hormone-releasing hormone (GHRH). It represents the first 29 residues of the native 44-amino acid GHRH sequence, which published research has identified as sufficient for binding and activation of the GHRH receptor on somatotroph cells of the anterior pituitary.

As the minimal active fragment of endogenous GHRH, Sermorelin has been studied in preclinical and in vitro research models focused on hypothalamic-pituitary axis signaling. Its research profile differs from synthetic GHRH analogs such as CJC-1295, which incorporates additional amino acid substitutions and a drug affinity complex (DAC) modification — resulting in distinct half-life and receptor-binding profiles in research contexts.

Published research has examined Sermorelin as a reference compound in somatotroph cell biology, GHRH receptor binding kinetics, and GH axis pulsatile research in preclinical models. Its historical study in pediatric and adult GH deficiency research models has generated a substantial peer-reviewed literature, making it a well-characterized tool compound for GH axis research.

Sequence Labs supplies Sermorelin as a lyophilized research compound in 5mg and 10mg vials. Each batch is independently verified by Krause Analytical using HPLC and mass spectrometry. For research use only. Not for human use.

Research Background

Published Research Areas

Published research has examined Sermorelin across five principal research contexts in preclinical and in vitro models. All references available via PubMed.

01
GHRH Receptor Mechanism Research
Published research has examined how the GHRH(1-29) fragment engages the GHRH receptor — a class B G protein-coupled receptor — in membrane-binding and cAMP-signaling studies. Sermorelin serves as a reference ligand in GHRH receptor pharmacology research.
02
Somatotroph Cell Biology Research
Published research has examined the role of GHRH signaling in somatotroph cell populations of the anterior pituitary. In vitro and preclinical cell culture models have used Sermorelin to study signal transduction cascades and cellular responses in somatotroph-lineage cells.
03
GH Axis Pulsatile Research
Published research has examined GH secretion pulsatility patterns in preclinical models. Sermorelin has been used as a tool compound in rodent model studies examining pulse amplitude, frequency, and regulatory feedback in the somatotropic axis.
04
Hypothalamic-Pituitary Research in Preclinical Models
Published research has examined the hypothalamic-pituitary signaling axis using GHRH analogs in preclinical models. Sermorelin's structural correspondence to the endogenous GHRH N-terminus has made it useful in studies of hypothalamic regulation of pituitary function.
05
GH Secretion Kinetics Research
Published research has examined the kinetic profiles of GH secretion in response to GHRH receptor stimulation in preclinical models. Studies have characterized clearance rates, concentration-response relationships, and the comparative kinetics of Sermorelin versus longer-acting GHRH analogs.
View Sermorelin Literature on PubMed

GHRH Analog Comparison

Sermorelin vs. CJC-1295

Both are synthetic GHRH analogs studied in GHRH receptor research. Published research has examined their distinct structural features and half-life profiles in preclinical models.

Sermorelin
This compound · GHRH(1-29)NH₂
FragmentN-terminal 29 AA of native GHRH
ModificationsNone — unmodified fragment
DAC ConjugationNo
Research Half-lifeShorter — endogenous-like profile
CAS86168-78-7
MW~3358 Da
Research ContextGHRH receptor binding, GH axis research
CJC-1295
Related analog · Modified GHRH
FragmentGHRH(1-29) + additional modifications
ModificationsAmino acid substitutions at multiple positions
DAC ConjugationYes (CJC-1295 with DAC)
Research Half-lifeExtended — DAC-mediated albumin binding
CAS863288-34-0
MW~3367 Da
Research ContextExtended half-life GH axis research models

Sequence Labs Supply

Sermorelin — Available Now

HPLC + MS verified by Krause Analytical. COA delivered via Finnrick Pulse. Catalog reviewed by Sabrina Runbeck, PA-C.

5mg
Sermorelin · GHRH(1-29)NH₂
~$40
  • Lyophilized research sample
  • HPLC + MS verified · Krause Analytical
  • COA via Finnrick Pulse
  • ≥99% purity verified
  • For research use only
Inquire · 5mg
Best Value
10mg
Sermorelin · GHRH(1-29)NH₂
~$65
  • Lyophilized research sample
  • HPLC + MS verified · Krause Analytical
  • COA via Finnrick Pulse
  • ≥99% purity verified
  • For research use only
Inquire · 10mg
⚗
Krause Analytical Independent HPLC + MS testing
📋
Finnrick Pulse COA delivery platform
🩺
Sabrina Runbeck PA-C Licensed PA-C catalog review
✓
≥99% Purity Verified on every batch

Laboratory Reference

Reconstitution Reference

Standard protocol for preparing a Sermorelin research sample. For research use only — not for human use.

1
Prepare Solvent
Use bacteriostatic water as the preferred solvent for Sermorelin research samples. Bacteriostatic water maintains stability and is the standard reconstitution medium for lyophilized peptide research compounds.
2
Introduce Solvent to Vial
Introduce solvent slowly into the lyophilized research sample vial by directing the liquid toward the inner wall — do not introduce solvent directly onto the lyophilized cake. Use sterile technique throughout.
3
Dissolve Gently
Gently swirl the vial until the lyophilized powder is fully dissolved. Do not vortex or shake vigorously, as mechanical agitation can degrade peptide structure. Allow time for complete dissolution at room temperature.
4
Storage of Reconstituted Sample
Store reconstituted research samples at 2–8°C. Lyophilized (unreconstituted) research compound should be stored at −20°C for long-term stability. Protect from light and repeated freeze-thaw cycles.
Research Use Only. This reconstitution reference is provided for laboratory research purposes. Sermorelin supplied by Sequence Labs is not for human use, veterinary use, or any clinical application. All handling should follow applicable laboratory safety protocols. Not for human consumption.

Frequently Asked Questions

Sermorelin is a synthetic 29-amino acid peptide corresponding to the biologically active N-terminal fragment of endogenous growth hormone-releasing hormone (GHRH). Formally designated GHRH(1-29)NH₂, it carries the molecular formula C₁₄₉H₂₄₆N₄₄O₄₂S and a molecular weight of approximately 3358 Da (CAS: 86168-78-7). Published research has examined this compound in the context of GHRH receptor binding and somatotroph cell research. Sequence Labs supplies it as a lyophilized research compound in 5mg and 10mg vials. For research use only.
Both Sermorelin and CJC-1295 are GHRH analogs used in preclinical GHRH receptor research. Sermorelin is the unmodified 29-amino acid N-terminal fragment of endogenous GHRH, while CJC-1295 incorporates additional amino acid substitutions and, in its DAC form, a drug affinity complex that extends its half-life profile through albumin binding. Published research has examined the differential pharmacokinetic profiles of these analogs in preclinical models. CJC-1295 is available separately from Sequence Labs.
Published research has examined Sermorelin in five principal areas: (1) GHRH receptor binding mechanism research, (2) somatotroph cell biology research in preclinical and in vitro models, (3) GH axis pulsatile activity studies in preclinical models, (4) hypothalamic-pituitary axis research, and (5) GH secretion kinetics research. An extensive peer-reviewed literature is indexed on PubMed under the search term "sermorelin GHRH."
Sequence Labs offers Sermorelin in two vial sizes: 5mg (approximately $40) and 10mg (approximately $65). Both sizes are lyophilized research compounds verified by HPLC and mass spectrometry via Krause Analytical, with COA available through Finnrick Pulse and catalog integrity reviewed by Sabrina Runbeck, PA-C. For research use only.
To prepare a Sermorelin research sample, introduce bacteriostatic water solvent slowly into the lyophilized vial by directing the liquid toward the inner wall using sterile technique. Gently swirl until fully dissolved — do not vortex or shake. Store the reconstituted research sample at 2–8°C. Lyophilized compound should be stored at −20°C for long-term stability. This reference is for laboratory research use only. Not for human use.
No. Sermorelin supplied by Sequence Labs is strictly for research use only. It is not for human use, veterinary use, or any clinical application. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. All customers must confirm they are qualified researchers or licensed professionals acquiring this compound for legitimate research purposes.

Continue Your GH Axis Research

Browse the full GH secretagogue catalog, view the CJC-1295 research page, or contact us directly with research compound inquiries.

Browse All Products CJC-1295 Research Page Contact Us