Compound Identity
Sermorelin at a Glance
Sermorelin is the N-terminal 29-amino-acid fragment of endogenous human growth hormone releasing hormone (GHRH). It preserves full biological activity of the native 44-residue GHRH and is the most extensively studied GHRH research analog. Binds the pituitary GHRH receptor and stimulates pulsatile GH release.
Compound Class
Growth hormone releasing hormone GHRH(1-29) — native fragment
CAS Number
86168-78-7
Molecular Formula
C₁₅₀H₂₄₄N₄₄O₄₁S
Molecular Weight
3,357.9 Da
Amino Acid Sequence
Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH₂
Receptor Target
Pituitary growth hormone releasing hormone receptor (GHRHR)
Half-Life
~10-15 minutes (rapid DPP-IV and endopeptidase clearance)
Research Background
Published Literature
Peer-reviewed research characterizes Sermorelin's receptor pharmacology, biochemistry, and biological activity across multiple domains. Sequence Labs supplies research-grade material; all product use is subject to laboratory research protocols and applicable regulations.
Native Receptor Binding
Sermorelin binds GHRHR with affinity equivalent to full-length GHRH(1-44). The N-terminal 29 residues contain the complete receptor-binding pharmacophore.
Pulsatile GH Release
Because sermorelin has a short half-life, it produces a discrete GH pulse and clears rapidly. Research uses this property to study endogenous GH pulsatility without sustained receptor saturation.
GHRH Reserve Test
Sermorelin is a classic pituitary GH-reserve stimulus in research protocols. A stimulated GH response confirms an intact somatotroph population.
Comparator to CJC-1295
Sermorelin serves as the unmodified reference in research comparing native GHRH kinetics to stabilized analogs (CJC-1295, Tesamorelin).
Independent research publications on Sermorelin are indexed in the NIH PubMed database. Consult primary literature for detailed methodology, dosing, and outcomes across research contexts.
Search PubMedSequence Labs Supply
Available Vial Sizes
All vials lyophilized under nitrogen with silver aluminum crimp cap and ivory-label spec. Manufacture and expiration dates printed. Batch-specific COA published in the COA library.
Sermorelin
2 mg
$35 / vial
Standard research vial. Silver crimp cap. Ivory label.
Sermorelin
5 mg
$65 / vial
Bulk research vial. Reconstitution flexibility.
Sermorelin
10 mg
$115 / vial
Institution / lab volume.
Quality Standards
HPLC + Mass Spec
Every batch, reverse-phase HPLC purity confirmation plus MS molecular weight identity. Chromatograms published.
ISO 17025 Lab
Analytical testing performed by ISO 17025 accredited independent laboratory. Full documentation.
Cold-Chain Shipped
Insulated packaging with -20°C gel packs. 3-day standard, overnight available.
Silver Crimp Caps
Tamper-evident silver aluminum crimp caps. Lyophilized under nitrogen. Ivory-label spec.
Reconstitution Reference
Standard Procedure
Reconstitution protocol for research-grade lyophilized Sermorelin. Adjust diluent volume to reach the working concentration required by the research protocol.
Prepare Materials
Remove vial from cold storage. Allow to reach room temperature. Sterile insulin syringe.
Sterilize
Swab rubber stopper of vial and bacteriostatic water vial with 70% isopropyl alcohol. Air-dry 30 seconds.
Draw Diluent
Draw the desired volume of bacteriostatic water. For 5 mg vial with 2 mL diluent, working concentration is 2,500 mcg/mL.
Add Diluent Slowly
Inject diluent down the inside wall of the vial. Do not spray onto lyophilized powder.
Gentle Dissolution
Swirl gently until dissolved. Do not shake or vortex — sermorelin is a linear peptide and can be denatured by mechanical stress.
Label + Store
Label vial with reconstitution date and concentration. Refrigerate 2-8°C. Reconstituted stability: ~2-3 weeks refrigerated with bacteriostatic water.
Frequently Asked Questions
Sermorelin FAQ
Is sermorelin the same as GHRH?
Sermorelin is the N-terminal 29-amino-acid fragment of endogenous human GHRH(1-44). It contains the full receptor-binding pharmacophore and is functionally equivalent to full-length GHRH at the pituitary receptor. The C-terminal residues 30-44 of native GHRH contribute to serum stability but not receptor activation.
How does sermorelin compare to CJC-1295?
Sermorelin is unmodified GHRH(1-29). CJC-1295 is GHRH(1-30) with four amino acid substitutions to resist enzymatic degradation, and optionally with an albumin-binding DAC linker. Both bind the same receptor but sermorelin has a half-life of ~12 minutes while CJC-1295 (with DAC) extends to ~8 days.
Why use sermorelin in research if CJC-1295 lasts longer?
The short half-life is the point. Sermorelin produces a discrete pulse that clears rapidly, allowing researchers to measure pituitary GH-reserve responses, characterize endogenous pulsatility, or maintain physiologic pulse patterns that continuous stimulation would abolish.
What testing is done on each sermorelin batch?
HPLC purity (typical >98%), mass spectrometry identity (3,357.9 Da target), endotoxin (LAL), water content, residual TFA, appearance. Full COA published per batch.
How should sermorelin be stored long-term?
Lyophilized sermorelin: -20°C long-term, 2-8°C for short-term (within 1 month). Reconstituted sermorelin: 2-8°C for 2-3 weeks with bacteriostatic water, or aliquoted and frozen at -20°C for extended storage (avoid freeze-thaw cycles).
Order Sermorelin Research Material
Batch-tested lyophilized vials with published COA. Standard 3-day cold-chain shipping $15. Overnight $30. Same-day dispatch on orders before 2pm ET.